Sitagliptin
Sitagliptin is commonly sold under the brand name Januvia.
Sitagliptin is an oral medication used to improve blood sugar control in adults with type 2 diabetes. It belongs to a class of drugs known as DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors), which work by enhancing the body’s natural ability to lower blood sugar levels. Sitagliptin works by inhibiting the enzyme DPP-4, which leads to increased levels of incretin hormones. These hormones help regulate blood sugar by stimulating insulin secretion from the pancreas and reducing glucagon levels, particularly after meals.Tablets & Capsules
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Our Inventory
Image | Name | Type | Strength | Manufacturer | Contact Us |
 | Glipta | Tablet | 50mg, 100mg | Beximco Pharmacuticals | |
 | Siglita | Tablet | 50mg | Square Pharmacuticals | |
 | Sitazid | Tablet | 50mg, 100mg | Eskayef Pharmaceuticals Ltd. |
Featured Sitagliptin Generics
Directions
The typical recommended dose of sitagliptin is 100 mg taken once daily. For patients with moderate renal impairment, the dose may be reduced to 50 mg once daily. Sitagliptin can be taken with or without food. Swallow the tablet whole with water; do not crush or chew. Regular monitoring of blood glucose levels is essential to evaluate the effectiveness of the treatment.
Special Precautions
- Pancreatitis Risk: There have been reports of pancreatitis in patients taking DPP-4 inhibitors, including sitagliptin. Patients should be monitored for symptoms such as severe abdominal pain.
- Renal Impairment: Dosage adjustments may be necessary for patients with renal impairment. Consult a healthcare provider for appropriate dosing.
- Pregnancy and Lactation: Consult a healthcare provider if pregnant, planning to become pregnant, or breastfeeding, as the safety of sitagliptin during these periods has not been fully established.
- Allergic Reactions: Be aware of potential allergic reactions, including skin rashes or swelling.
Side Effects
Common side effects may include:
- Nasopharyngitis (cold symptoms)
- Headache
- Upper respiratory tract infections
- Diarrhea
Serious side effects can include:
- Pancreatitis (e.g., severe abdominal pain)
- Allergic reactions (e.g., rash, itching, swelling)
- Joint pain or discomfort
Missed Dosage
If a dose is missed, take it as soon as remembered on the same day. If it is almost time for the next dose, skip the missed dose—do not double up to make up for a missed dose.
Storage Requirements
Store sitagliptin at room temperature (between 20°C to 25°C or 68°F to 77°F). Keep away from moisture and direct light. Ensure it is out of reach of children and pets.